Endothelial cell fate commitment

Across TCGA cell cohorts, RNA activity of the Endothelial cell fate commitment pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDM2A, HOXB8, and AWAT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KDM2A grouped by Endothelial cell fate commitment-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KDM2A →	-0.351	-0.189	<.001	<.001	3	4
OVARY	HOXB8 →	-0.270	-0.213	.006	.002	3	4
UPPER_AERODIGESTIVE_TRACT	AWAT2 →	-0.332	-0.260	<.001	.007	3	4
SKIN	SIX3 →	-0.098	-0.156	.008	<.001	3	4
LUNG_NSCLC_LUAD	STARD9 →	-0.290	-0.199	.004	.006	3	4
LIVER	CCNI2 →	-0.240	-0.293	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KDM2A by Endothelial cell fate commitment activity — BREAST

Explore this box plot interactively →