Blood vessel endothelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Blood vessel endothelial cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAMB1, CRMP1, and LAMA4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Blood vessel endothelial cell differentiation activity versus LAMB1 in CCRCC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LAMB1 →	+0.547	+0.085	<.001	<.001	3	7
CCRCC	CRMP1 →	+0.736	+0.085	<.001	<.001	3	6
OV	LAMA4 →	+0.557	+0.051	<.001	.001	3	6
PDAC	NID1 →	+0.421	+0.042	<.001	<.001	3	6
OV	NID2 →	+0.587	+0.067	<.001	<.001	3	6
CCRCC	SEPTIN4 →	+0.393	+0.069	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060837 vs LAMB1 — CCRCC

Explore this scatter interactively →