Blood vessel endothelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Blood vessel endothelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDN, SSPN, and TRIP4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Blood vessel endothelial cell differentiation activity versus NDN in KIDNEY (Pearson r = 0.98).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NDN →	+3.401	+1.476	.002	<.001	2	3
SKIN	SSPN →	+3.300	+2.412	<.001	.004	2	3
CNS	TRIP4 →	+0.445	+0.710	.005	.006	3	2
CNS	DEF8 →	-0.543	-0.899	.006	.008	3	2
CNS	APRT →	-0.856	-0.896	.001	.004	3	2
CNS	FMN1 →	+1.309	+0.912	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060837 vs NDN — KIDNEY

Explore this scatter interactively →