Lymphatic endothelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Lymphatic endothelial cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAMA4, LAMB1, and ERG_S81, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphatic endothelial cell differentiation activity versus LAMA4 in UCEC (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LAMA4 →	+0.730	+0.095	<.001	<.001	3	8
UCEC	LAMB1 →	+0.434	+0.083	<.001	<.001	3	8
CCRCC	ERG_S81 →	+0.903	+0.101	<.001	<.001	3	8
UCEC	ANGPTL2 →	+0.902	+0.121	<.001	<.001	3	8
CCRCC	RASIP1_S41 →	+0.519	+0.072	<.001	<.001	3	8
OV	TNS2_S102 →	+1.008	+0.058	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060836 vs LAMA4 — UCEC

Explore this scatter interactively →