Lymphatic endothelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Lymphatic endothelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMTNL1, PROX1, and SQSTM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphatic endothelial cell differentiation activity versus SMTNL1 in COAD (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SMTNL1 →	-0.553	-0.364	.003	.003	3	5
UCEC	PROX1 →	+2.012	+0.592	<.001	<.001	2	6
GBM	SQSTM1 →	-0.589	-0.251	<.001	<.001	3	5
LUAD	PARP14 →	-0.495	-0.241	.006	.003	3	5
BRCA	PSMB10 →	-0.843	-0.240	<.001	.003	3	5
BRCA	TYMP →	-0.928	-0.236	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060836 vs SMTNL1 — COAD

Explore this scatter interactively →