Hair follicle placode formation

Across TCGA patient cohorts, RNA activity of the Hair follicle placode formation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCA, JADE3, and H2BC21, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hair follicle placode formation activity versus FANCA in HNSC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FANCA →	+0.395	+0.124	.004	.005	3	4
PDAC	JADE3 →	+0.227	+0.158	.003	.006	3	4
LSCC	H2BC21 →	+0.410	+0.178	.005	.002	3	4
GBM	LDB3 →	-0.906	-0.128	.001	.002	3	3
HNSC	ALDH1L2 →	-0.568	-0.182	.004	.005	3	3
GBM	HECW2 →	-0.500	-0.114	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060789 vs FANCA — HNSC

Explore this scatter interactively →