Hair follicle placode formation

Across TCGA cell cohorts, RNA activity of the Hair follicle placode formation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP188, CMC2, and ARID1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hair follicle placode formation activity versus NUP188 in BLOOD_Leukemia (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NUP188 →	+0.567	+0.537	<.001	<.001	3	4
OVARY	CMC2 →	-0.740	-0.144	<.001	.001	3	4
BLOOD_Leukemia	ARID1A →	+1.025	+0.615	<.001	.008	3	4
BLOOD_Leukemia	SOGA1 →	+0.724	+0.533	<.001	<.001	3	4
LUNG_NSCLC_LUAD	FNDC5 →	+0.477	+0.264	.001	.009	3	3
LUNG_NSCLC_LUAD	TIMP2 →	+1.241	+0.395	.006	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060789 vs NUP188 — BLOOD_Leukemia

Explore this scatter interactively →