Regulation of androgen receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of androgen receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLF12, ZNF678, and POU2F1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of androgen receptor signaling pathway activity versus KLF12 in HNSC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KLF12 →	+0.672	+0.842	.007	.002	3	4
LSCC	ZNF678 →	+0.480	+0.241	.003	.001	3	4
LUAD	POU2F1 →	+0.232	+0.197	.004	.001	3	4
UCEC	TMEM81 →	+0.500	+0.167	.004	.006	3	4
UCEC	ATP6V0E1P3 →	+0.736	+0.138	<.001	.002	3	4
LUAD	PDZK1P1 →	+0.429	+0.221	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060765 vs KLF12 — HNSC

Explore this scatter interactively →