Regulation of androgen receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of androgen receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM255B, MEX3A, and FGF11, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of androgen receptor signaling pathway activity versus TMEM255B in LUNG_NSCLC_LUSC (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TMEM255B →	-2.965	-0.304	.002	.009	2	7
STOMACH	MEX3A →	+3.065	+0.287	<.001	<.001	3	6
OVARY	FGF11 →	+1.991	+0.127	.001	.003	3	6
OVARY	CLIC1 →	-0.610	-0.125	.008	.001	3	6
STOMACH	MAP2K6 →	+2.650	+0.230	<.001	.004	3	6
BLOOD_Leukemia	CNOT9 →	+0.365	+0.115	.008	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060765 vs TMEM255B — LUNG_NSCLC_LUSC

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