Positive regulation of response to cytokine stimulus

Across TCGA patient cohorts, RNA activity of the Positive regulation of response to cytokine stimulus pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VIPR1, GBP2, and PSMB9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of response to cytokine stimulus activity versus VIPR1 in GBM (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	VIPR1 →	-0.494	-0.131	<.001	.003	3	6
GBM	GBP2 →	+1.273	+0.243	<.001	<.001	3	5
LSCC	PSMB9 →	+0.551	+0.136	<.001	<.001	3	5
BRCA	SESN1 →	-0.648	-0.138	<.001	.001	3	5
GBM	FAM13C →	-0.677	-0.135	.003	.009	3	5
GBM	MAGI1 →	-0.844	-0.170	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060760 vs VIPR1 — GBM

Explore this scatter interactively →