Positive regulation of response to cytokine stimulus

Across TCGA cell cohorts, RNA activity of the Positive regulation of response to cytokine stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD79A, PLA2G4A, and SDSL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of response to cytokine stimulus activity versus CD79A in BLOOD_Leukemia (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CD79A →	+3.978	+0.240	<.001	<.001	3	4
BLOOD_Leukemia	PLA2G4A →	-1.992	-0.233	<.001	<.001	3	4
LUNG_SCLC	SDSL →	-2.100	-0.293	<.001	.004	3	4
PANCREAS	CYP24A1 →	+2.972	+0.325	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	KLF12 →	+0.950	+0.237	.001	<.001	3	4
BLOOD_Leukemia	SYNE2 →	+2.100	+0.191	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060760 vs CD79A — BLOOD_Leukemia

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