Positive regulation of mast cell chemotaxis

Across TCGA patient cohorts, RNA activity of the Positive regulation of mast cell chemotaxis pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNKS1BP1, ITGA5, and ARHGEF10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mast cell chemotaxis activity versus TNKS1BP1 in HNSC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TNKS1BP1 →	+0.370	+0.110	<.001	<.001	3	7
BRCA	ITGA5 →	+0.465	+0.058	<.001	<.001	3	7
PDAC	ARHGEF10 →	+0.223	+0.040	<.001	.004	3	7
HNSC	LDHA →	+0.495	+0.142	<.001	<.001	3	7
UCEC	TRMT1L →	-0.280	-0.077	<.001	<.001	3	6
PDAC	C4BPA →	+0.487	+0.051	.004	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060754 vs TNKS1BP1 — HNSC

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