Regulation of mast cell chemotaxis

Across TCGA patient cohorts, RNA activity of the Regulation of mast cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAT2, MNDA, and GIMAP8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mast cell chemotaxis activity versus LAT2 in LSCC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LAT2 →	+0.416	+0.433	<.001	<.001	3	6
BRCA	MNDA →	+0.646	+0.377	.005	.001	3	6
HNSC	GIMAP8 →	+0.610	+0.126	.002	.002	3	5
GBM	CYTH4 →	+0.818	+0.293	<.001	<.001	3	5
BRCA	DOCK10 →	+0.645	+0.254	<.001	.003	3	5
GBM	LCP1 →	+0.694	+0.254	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060753 vs LAT2 — LSCC

Explore this scatter interactively →