Regulation of mast cell chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of mast cell chemotaxis pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGF, VEGFD, and KAT2A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PGF grouped by Regulation of mast cell chemotaxis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PGF →	-0.290	-1.324	<.001	<.001	3	9
SOFT_TISSUE	VEGFD →	-0.606	-1.807	<.001	.003	3	8
LIVER	KAT2A →	+0.243	+1.446	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	RIN3 →	-0.414	-1.692	<.001	.002	3	4
BREAST	VEGFA →	-0.171	-0.945	<.001	<.001	3	4
BLOOD_Leukemia	LRRC4 →	-0.231	-1.925	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PGF by Regulation of mast cell chemotaxis activity — CNS

Explore this box plot interactively →