Mammary gland alveolus development

Across TCGA cell cohorts, RNA activity of the Mammary gland alveolus development pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCND1, SHCBP1, and PRDM2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCND1 grouped by Mammary gland alveolus development-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCND1 →	-0.579	-0.206	<.001	.001	2	7
BLOOD_Myeloma	SHCBP1 →	-0.230	-0.312	.002	<.001	3	5
BREAST	PRDM2 →	+0.137	+0.229	<.001	<.001	3	4
BREAST	TEX14 →	+0.099	+0.215	.001	.005	3	4
BREAST	ELL3 →	-0.292	-0.268	.001	.003	3	4
BREAST	ZNF587 →	-0.203	-0.231	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCND1 by Mammary gland alveolus development activity — LARGE_INTESTINE

Explore this box plot interactively →