Mammary gland alveolus development

Across TCGA cell cohorts, RNA activity of the Mammary gland alveolus development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRPK3, PLBD1, and KIF13A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRPK3 grouped by Mammary gland alveolus development-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SRPK3 →	-0.602	-1.004	.004	.002	3	4
STOMACH	PLBD1 →	+3.393	+0.238	.006	.003	3	4
OESOPHAGUS	KIF13A →	-1.393	-1.284	<.001	.004	3	3
BLOOD_Leukemia	DNLZ →	-1.199	-1.231	.003	<.001	3	3
SKIN	SOD1 →	-0.349	-0.800	.002	.002	3	3
BLOOD_Leukemia	CRACD →	-2.855	-1.075	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRPK3 by Mammary gland alveolus development activity — SKIN

Explore this box plot interactively →