Mammary gland branching involved in pregnancy

pathway activity — cross-omics
GO:0060745Cross-omicsRNA → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Mammary gland branching involved in pregnancy pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VDR, WNT4, and CARMIL2, each associated with the pathway in up to 22 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
ACCVDR →+1.451+0.059<.001<.001322
ACCWNT4 →+2.267+0.075<.001<.001319
THYMCARMIL2 →-1.638-0.074<.001<.001317
HNSCMEI1 →-0.668-0.051<.001<.001316
THYMHCST →-1.002-0.062<.001<.001315
KICHARID5A →-0.964-0.059.001.005315
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration