Mammary gland branching involved in pregnancy

pathway activity — cross-omics
GO:0060745Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Mammary gland branching involved in pregnancy pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IGF2BP2, SLC25A19, and PDPK1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECIGF2BP2 →-1.168-0.109<.001<.00136
BRCASLC25A19 →-0.464-0.114.005<.00135
BRCAPDPK1 →+0.216+0.083<.001<.00135
LSCCRIF1_S2393 →-0.636-0.084<.001<.00134
COADAKAP12_S1331 →-0.364-0.061<.001<.00134
UCECMCAM →-0.415-0.072.001.00834
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration