Mammary gland branching involved in pregnancy

pathway activity — cross-omics
GO:0060745Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Mammary gland branching involved in pregnancy pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYTL2, IGLV7-46, and RNU6-932P, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCSYTL2 →-0.686-0.431.002.00633
LSCCIGLV7-46 →-1.243-0.483.005.00233
GBMRNU6-932P →-0.643-0.242.001<.00133
LSCCRN7SKP195 →-0.437-0.348.002.00633
LSCCIFNG-AS1 →-0.570-0.409.008.00733
BRCAOCA2 →-0.791-0.672<.001.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration