Epithelial cell differentiation involved in prostate gland development

Across TCGA patient cohorts, RNA activity of the Epithelial cell differentiation involved in prostate gland development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARPC1B, COQ7, and PKP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cell differentiation involved in prostate gland development activity versus ARPC1B in GBM (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARPC1B →	-0.334	-0.059	.001	.003	3	6
LSCC	COQ7 →	+0.266	+0.065	.002	.002	3	6
GBM	PKP4 →	+0.420	+0.096	<.001	<.001	3	6
GBM	ARPC5 →	-0.210	-0.073	<.001	<.001	3	5
GBM	RPS6KA5 →	+0.453	+0.080	.001	.001	3	5
GBM	SERPINB8 →	-0.425	-0.078	.008	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060742 vs ARPC1B — GBM

Explore this scatter interactively →