Epithelial cell differentiation involved in prostate gland development

Across TCGA patient cohorts, RNA activity of the Epithelial cell differentiation involved in prostate gland development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF425, C14orf93, and PNN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cell differentiation involved in prostate gland development activity versus ZNF425 in BRCA (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF425 →	+0.380	+0.152	.006	.003	3	5
PDAC	C14orf93 →	+0.207	+0.151	.002	.008	3	4
PDAC	PNN →	+0.339	+0.217	.002	<.001	3	4
LSCC	PAX9 →	+1.675	+0.534	<.001	.001	3	4
OV	CSF2RA →	-0.789	-0.170	.009	.004	2	5
OV	SMYD3-IT1 →	+0.164	+0.159	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060742 vs ZNF425 — BRCA

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