Epithelial cell differentiation involved in prostate gland development

Across TCGA cell cohorts, RNA activity of the Epithelial cell differentiation involved in prostate gland development pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGFR2, CCDC85B, and TC2N, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial cell differentiation involved in prostate gland development activity versus FGFR2 in LIVER (Pearson r = -0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	FGFR2 →	-3.571	-0.340	<.001	<.001	3	17
SOFT_TISSUE	CCDC85B →	+1.689	+0.116	<.001	.003	3	10
URINARY_TRACT	TC2N →	-2.354	-0.225	.003	.001	3	9
PANCREAS	HSD11B2 →	-1.341	-0.209	.001	.006	3	8
URINARY_TRACT	CDS1 →	-2.365	-0.213	.004	.005	3	8
LIVER	FGFR3 →	-3.248	-0.278	.001	<.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060742 vs FGFR2 — LIVER

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