Prostate gland growth

Across TCGA patient cohorts, RNA activity of the Prostate gland growth pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRRF, TADA1, and CTSC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prostate gland growth activity versus MRRF in GBM (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MRRF →	+0.324	+0.829	.002	<.001	3	5
LSCC	TADA1 →	+0.520	+0.347	.004	.009	3	5
BRCA	CTSC →	-0.559	-0.270	<.001	.001	3	5
BRCA	UBE3A →	+0.439	+0.267	.002	.004	3	5
BRCA	PTPRA →	+0.409	+0.390	<.001	.004	3	5
LSCC	CYTH4 →	-0.674	-0.383	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060736 vs MRRF — GBM

Explore this scatter interactively →