Chorionic trophoblast cell differentiation

Across TCGA patient cohorts, RNA activity of the Chorionic trophoblast cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAFAH2, APBB2, and FDXR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chorionic trophoblast cell differentiation activity versus PAFAH2 in COAD (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PAFAH2 →	-0.342	-0.283	.004	.004	3	3
COAD	APBB2 →	+0.724	+0.200	<.001	.007	3	3
CCRCC	FDXR →	-0.426	-0.720	.009	<.001	3	3
CCRCC	IDH3A →	-0.222	-0.563	.001	<.001	3	3
CCRCC	KBTBD11 →	-0.733	-0.571	.009	.002	3	3
UCEC	SMIM6 →	-1.328	-0.324	<.001	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060718 vs PAFAH2 — COAD

Explore this scatter interactively →