Chorionic trophoblast cell differentiation

Across TCGA cell cohorts, RNA activity of the Chorionic trophoblast cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPA, TMEM106B, and RHEB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CENPA grouped by Chorionic trophoblast cell differentiation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CENPA →	-0.454	-0.607	.007	.008	3	4
KIDNEY	TMEM106B →	-1.101	-0.879	.004	.008	3	3
BLOOD_Leukemia	RHEB →	-0.633	-0.548	.006	.005	3	3
PANCREAS	C5orf60 →	+0.054	+0.877	.001	.005	3	3
UPPER_AERODIGESTIVE_TRACT	LAMA3 →	-1.756	-0.822	.007	.007	3	3
UPPER_AERODIGESTIVE_TRACT	COL17A1 →	-1.984	-0.809	.008	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CENPA by Chorionic trophoblast cell differentiation activity — CNS

Explore this box plot interactively →