Chorion development

Across TCGA patient cohorts, RNA activity of the Chorion development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DZIP1L, AGBL2, and TMEM45A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chorion development activity versus DZIP1L in UCEC (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DZIP1L →	-1.299	-0.371	<.001	<.001	3	4
UCEC	AGBL2 →	-0.804	-0.331	.008	.002	3	4
HNSC	TMEM45A →	+1.412	+0.455	<.001	.004	3	4
BRCA	SPECC1L →	-0.420	-0.771	<.001	.002	3	3
CCRCC	PTCD1 →	-0.177	-0.563	.001	<.001	3	3
CCRCC	ZNF45 →	-0.287	-0.685	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060717 vs DZIP1L — UCEC

Explore this scatter interactively →