Chorion development

Across TCGA cell cohorts, RNA activity of the Chorion development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCF2, NEK8, and MON1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ABCF2 grouped by Chorion development-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ABCF2 →	-0.801	-0.916	.002	.002	3	4
OVARY	NEK8 →	-0.992	-0.941	.001	.001	3	4
BLOOD_Lymphoma	MON1B →	-0.990	-1.723	<.001	<.001	3	3
BLOOD_Lymphoma	EFR3A →	-1.882	-1.607	.001	<.001	3	3
BLOOD_Lymphoma	TTC30A →	-0.708	-1.205	.005	.006	3	3
KIDNEY	PCMT1 →	+0.871	+0.701	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABCF2 by Chorion development activity — SKIN

Explore this box plot interactively →