Chorion development

Across TCGA cell cohorts, RNA activity of the Chorion development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are E2F8, KIFC1, and FOXM1, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chorion development activity versus E2F8 in OESOPHAGUS (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	E2F8 →	+1.505	+0.909	.001	.007	2	18
PANCREAS	KIFC1 →	+1.431	+0.983	<.001	<.001	3	17
OVARY	FOXM1 →	+1.606	+1.060	<.001	<.001	3	16
BLOOD_Lymphoma	ESPL1 →	+1.448	+0.215	<.001	.009	3	15
PANCREAS	SMC2 →	+1.490	+0.752	<.001	.003	3	15
PANCREAS	BUB1B →	+1.499	+0.790	<.001	.006	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060717 vs E2F8 — OESOPHAGUS

Explore this scatter interactively →