Chorion development

Across TCGA cell cohorts, RNA activity of the Chorion development pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UHRF1, GSTK1, and PDIA5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chorion development activity versus UHRF1 in BLOOD_Leukemia (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UHRF1 →	+2.012	+0.195	<.001	<.001	3	4
BLOOD_Leukemia	GSTK1 →	-1.213	-0.130	<.001	<.001	3	4
BLOOD_Leukemia	PDIA5 →	-0.981	-0.144	.001	.001	3	4
BLOOD_Leukemia	CDCA8 →	+0.889	+0.205	<.001	<.001	3	3
BLOOD_Leukemia	RDH13 →	-1.251	-0.150	.002	.005	3	3
LARGE_INTESTINE	RNMT →	+0.832	+0.107	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060717 vs UHRF1 — BLOOD_Leukemia

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