Labyrinthine layer blood vessel development

Across TCGA patient cohorts, RNA activity of the Labyrinthine layer blood vessel development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HDGFL3, ARHGEF17_S527, and PALM, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Labyrinthine layer blood vessel development activity versus HDGFL3 in BRCA (Pearson r = -0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HDGFL3 →	+0.419	+0.019	.004	.003	3	7
GBM	ARHGEF17_S527 →	+0.494	+0.057	.003	.004	3	5
HNSC	PALM →	+0.439	+0.053	.003	.004	2	6
CCRCC	RPL7 →	-0.234	-0.043	.005	.009	2	6
HNSC	N4BP1 →	-0.169	-0.039	.004	.006	3	5
BRCA	SCARF2_S687 →	+0.593	+0.026	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060716 vs HDGFL3 — BRCA

Explore this scatter interactively →