Labyrinthine layer blood vessel development

Across TCGA patient cohorts, RNA activity of the Labyrinthine layer blood vessel development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL24A1, LRRC36, and MIRLET7BHG, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Labyrinthine layer blood vessel development activity versus COL24A1 in LUAD (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	COL24A1 →	+0.491	+0.160	.004	.003	3	3
GBM	LRRC36 →	-0.508	-0.125	<.001	.002	3	3
CCRCC	MIRLET7BHG →	+0.298	+0.170	.005	.003	3	3
CCRCC	MIR545 →	+0.610	+0.271	<.001	<.001	3	3
CCRCC	MIR3619 →	+0.811	+0.285	.002	.005	3	3
BRCA	NNMT →	+0.699	+0.278	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060716 vs COL24A1 — LUAD

Explore this scatter interactively →