Labyrinthine layer morphogenesis

Across TCGA patient cohorts, RNA activity of the Labyrinthine layer morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNG2, FLI1, and TPI1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Labyrinthine layer morphogenesis activity versus GNG2 in GBM (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GNG2 →	-0.663	-0.131	.002	.001	3	6
HNSC	FLI1 →	-0.531	-0.181	.001	<.001	3	5
LSCC	TPI1 →	+0.412	+0.146	.003	.002	3	4
LSCC	PXK →	-0.284	-0.170	.002	.005	3	4
LSCC	NME1 →	+0.476	+0.195	.006	.001	3	4
GBM	PPP1R16B →	-1.301	-0.161	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060713 vs GNG2 — GBM

Explore this scatter interactively →