Labyrinthine layer morphogenesis

Across TCGA cell cohorts, RNA activity of the Labyrinthine layer morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF3M, MRPS26, and LRRC41, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF3M grouped by Labyrinthine layer morphogenesis-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	EIF3M →	-0.553	-1.483	.006	.001	3	4
PANCREAS	MRPS26 →	-1.241	-1.830	.003	<.001	2	4
PANCREAS	LRRC41 →	-0.918	-1.540	<.001	<.001	3	3
PANCREAS	RPS2 →	-0.931	-1.599	.003	<.001	3	3
SOFT_TISSUE	RP2 →	+0.520	+1.041	.007	.006	3	3
BLOOD_Lymphoma	SNX6 →	+1.470	+1.745	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF3M by Labyrinthine layer morphogenesis activity — SOFT_TISSUE

Explore this box plot interactively →