Labyrinthine layer development

Across TCGA patient cohorts, RNA activity of the Labyrinthine layer development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL3A1, HMCN1, and VCL_S726, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Labyrinthine layer development activity versus COL3A1 in BRCA (Pearson r = 0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COL3A1 →	+0.445	+0.021	<.001	<.001	3	6
CCRCC	HMCN1 →	+0.440	+0.037	.005	.001	3	5
PDAC	VCL_S726 →	+0.285	+0.036	.009	.001	3	5
BRCA	SERPINF1 →	+0.572	+0.023	.001	.007	3	4
BRCA	CFH →	+0.396	+0.022	.007	.008	3	4
COAD	COMP →	+0.892	+0.028	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060711 vs COL3A1 — BRCA

Explore this scatter interactively →