Labyrinthine layer development

Across TCGA cell cohorts, RNA activity of the Labyrinthine layer development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF11, PCNX2, and TNFSF10, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Labyrinthine layer development activity versus ARHGEF11 in BLOOD_Myeloma (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ARHGEF11 →	+1.777	+0.359	<.001	<.001	3	3
BLOOD_Lymphoma	PCNX2 →	+1.654	+0.283	.003	.002	3	3
BLOOD_Leukemia	TNFSF10 →	+2.315	+0.286	.007	.005	3	3
KIDNEY	C12orf65 →	-0.401	-0.506	.005	.004	3	3
BLOOD_Lymphoma	P2RX5 →	-4.494	-0.365	<.001	.001	3	2
BLOOD_Myeloma	GSR →	+0.889	+0.359	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060711 vs ARHGEF11 — BLOOD_Myeloma

Explore this scatter interactively →