Chorio-allantoic fusion

Across TCGA patient cohorts, RNA activity of the Chorio-allantoic fusion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MXRA5, LEF1, and COL3A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chorio-allantoic fusion activity versus MXRA5 in GBM (Pearson r = -0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MXRA5 →	+0.565	+0.103	.001	<.001	3	7
HNSC	LEF1 →	+0.735	+0.147	<.001	<.001	3	6
CCRCC	COL3A1 →	+0.532	+0.071	.002	<.001	3	6
PDAC	CRTAP →	+0.292	+0.055	<.001	<.001	3	6
UCEC	CLINT1 →	-0.255	-0.089	.002	.007	3	5
HNSC	CUTC →	-0.316	-0.095	.006	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060710 vs MXRA5 — GBM

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