Chorio-allantoic fusion

pathway activity — cross-omics
GO:0060710Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Chorio-allantoic fusion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAS2, FSTL1, and LAMB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAHAS2 →+0.870+0.264.002<.00136
BRCAFSTL1 →+0.755+0.195.001.00135
BRCALAMB1 →+1.011+0.243<.001<.00135
BRCAVIM →+0.934+0.252<.001<.00135
BRCALTBP2 →+0.681+0.186.003.00335
GBMLGALS1 →+0.794+0.153<.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration