Chorio-allantoic fusion

Across TCGA cell cohorts, RNA activity of the Chorio-allantoic fusion pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCM1, FAM83H, and CDSN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PCM1 grouped by Chorio-allantoic fusion-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PCM1 →	+0.318	+1.436	<.001	.003	3	5
SKIN	FAM83H →	+0.118	+0.882	.001	.001	3	4
KIDNEY	CDSN →	-0.185	-1.337	.007	.008	3	4
BLOOD_Myeloma	CLPTM1L →	+0.463	+2.063	.006	<.001	3	3
URINARY_TRACT	FOXJ3 →	+0.314	+1.819	.007	<.001	3	3
URINARY_TRACT	HECW1 →	+0.265	+1.351	<.001	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PCM1 by Chorio-allantoic fusion activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →