Cell differentiation involved in embryonic placenta development

Across TCGA patient cohorts, RNA activity of the Cell differentiation involved in embryonic placenta development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AZU1, JUNB, and SCLY, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell differentiation involved in embryonic placenta development activity versus AZU1 in BRCA (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AZU1 →	+1.056	+0.052	<.001	<.001	3	7
GBM	JUNB →	+0.369	+0.059	<.001	<.001	3	7
BRCA	SCLY →	-0.287	-0.039	.002	<.001	3	6
LSCC	SLC2A1 →	+0.640	+0.052	.004	<.001	3	6
BRCA	CHDH →	-0.462	-0.040	<.001	<.001	3	6
GBM	PURA →	-0.436	-0.073	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060706 vs AZU1 — BRCA

Explore this scatter interactively →