Regulation of ribonuclease activity

Across TCGA cell cohorts, RNA activity of the Regulation of ribonuclease activity pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM33, FAM199X, and NFXL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM33 grouped by Regulation of ribonuclease activity-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TMEM33 →	+0.733	+0.224	.005	.001	3	3
STOMACH	FAM199X →	+0.920	+0.271	.008	<.001	3	3
STOMACH	NFXL1 →	+0.798	+0.260	.003	.004	3	3
BLOOD_Lymphoma	CBR1 →	-3.314	-0.270	.004	.001	3	3
URINARY_TRACT	TUBGCP5 →	+1.910	+0.215	.001	.007	3	3
BLOOD_Myeloma	ETFBKMT →	-0.506	-1.704	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM33 by Regulation of ribonuclease activity activity — STOMACH

Explore this box plot interactively →