Regulation of ribonuclease activity

Across TCGA cell cohorts, RNA activity of the Regulation of ribonuclease activity pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGAV, MRGPRX2, and LOXHD1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGAV grouped by Regulation of ribonuclease activity-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ITGAV →	-0.549	-1.469	.003	<.001	3	3
OVARY	MRGPRX2 →	+0.198	+1.469	.002	<.001	3	3
BREAST	LOXHD1 →	-0.280	-1.640	<.001	<.001	3	3
STOMACH	RASD1 →	+0.220	+1.394	.007	.007	3	3
LUNG_NSCLC_LUAD	SHB →	+0.184	+1.226	.008	.001	3	2
LUNG_NSCLC_LUAD	TGS1 →	+0.144	+1.302	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGAV by Regulation of ribonuclease activity activity — OVARY

Explore this box plot interactively →