Regulation of ribonuclease activity

Across TCGA cell cohorts, RNA activity of the Regulation of ribonuclease activity pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACSF3, ANKRD11, and FNBP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ribonuclease activity activity versus ACSF3 in STOMACH (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ACSF3 →	+0.949	+1.721	.006	<.001	3	6
STOMACH	ANKRD11 →	+1.522	+1.802	.006	<.001	3	5
LARGE_INTESTINE	FNBP4 →	+0.602	+0.928	.005	.004	3	5
STOMACH	NCR3LG1 →	+2.234	+1.392	.002	.007	3	4
CNS	ZNF587B →	+0.836	+0.939	<.001	.004	3	4
SKIN	NAF1 →	+0.401	+1.693	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060700 vs ACSF3 — STOMACH

Explore this scatter interactively →