Regulation of branching involved in salivary gland morphogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of branching involved in salivary gland morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARMCX4, AIP, and NCOA3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARMCX4 grouped by Regulation of branching involved in salivary gland morphogenesis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ARMCX4 →	-1.589	-1.329	<.001	<.001	3	4
LUNG_NSCLC_LUSC	AIP →	-0.583	-1.522	.003	<.001	2	4
URINARY_TRACT	NCOA3 →	+1.492	+1.765	.003	<.001	3	3
SOFT_TISSUE	ME3 →	-3.565	-1.747	.006	.001	3	3
LUNG_NSCLC_LUSC	UBALD1 →	-0.764	-1.371	.003	.002	3	3
LUNG_NSCLC_LUSC	INTU →	-0.854	-1.352	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARMCX4 by Regulation of branching involved in salivary gland morphogenesis activity — STOMACH

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