Regulation of morphogenesis of a branching structure

Across TCGA patient cohorts, RNA activity of the Regulation of morphogenesis of a branching structure pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AFF3, FNDC5, and CD200, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of morphogenesis of a branching structure activity versus AFF3 in BRCA (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AFF3 →	+1.407	+0.196	<.001	.003	3	5
GBM	FNDC5 →	+0.854	+0.753	<.001	.005	3	4
HNSC	CD200 →	+0.780	+0.469	<.001	.005	3	4
BRCA	ACVR2B →	+0.301	+0.191	.001	.004	3	4
BRCA	GFRA1 →	+2.146	+0.214	<.001	.001	3	4
BRCA	PABPC5 →	+0.689	+0.244	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060688 vs AFF3 — BRCA

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