Regulation of prostatic bud formation

pathway activity — cross-omics
GO:0060685Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of prostatic bud formation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEM1, FKBP7, and SYNDIG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECSEM1 →+0.529+0.718.001.00135
HNSCFKBP7 →+0.871+0.282<.001.00335
PDACSYNDIG1 →+1.019+0.073<.001<.00125
PDACRAB32 →+0.614+0.120<.001<.00134
PDACCCNI →+0.583+0.128<.001<.00134
PDACJAM3 →+0.782+0.111<.001.00634
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

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