Placenta blood vessel development

Across TCGA patient cohorts, RNA activity of the Placenta blood vessel development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, RPL7, and SPAG9_S251, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Placenta blood vessel development activity versus RPL5 in OV (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPL5 →	-0.150	-0.045	.008	.002	3	6
HNSC	RPL7 →	-0.183	-0.046	<.001	.009	2	6
GBM	SPAG9_S251 →	-0.388	-0.051	<.001	<.001	3	5
PDAC	EIF4G1 →	-0.176	-0.061	.003	<.001	3	5
CCRCC	FBLN5 →	+1.085	+0.076	<.001	<.001	3	5
PDAC	MAP2_S833 →	+0.423	+0.038	.009	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060674 vs RPL5 — OV

Explore this scatter interactively →