Placenta blood vessel development

Across TCGA patient cohorts, RNA activity of the Placenta blood vessel development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTGDS, CCDC69, and TIPIN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Placenta blood vessel development activity versus PTGDS in GBM (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PTGDS →	-0.849	-0.123	.002	.002	3	4
GBM	CCDC69 →	-0.589	-0.153	.002	.002	3	4
COAD	TIPIN →	+0.566	+0.183	<.001	<.001	3	4
LUAD	RBFA →	+0.361	+0.141	<.001	<.001	3	3
GBM	RASAL1 →	-0.909	-0.119	<.001	.003	3	3
GBM	HARS2 →	+0.132	+0.145	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060674 vs PTGDS — GBM

Explore this scatter interactively →