Embryonic placenta morphogenesis

Across TCGA patient cohorts, RNA activity of the Embryonic placenta morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYO18A, SPN_S363, and IGFBP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic placenta morphogenesis activity versus MYO18A in HNSC (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MYO18A →	-0.259	-0.081	<.001	<.001	3	6
HNSC	SPN_S363 →	-0.791	-0.092	<.001	.001	3	5
LSCC	IGFBP2 →	+1.084	+0.078	<.001	<.001	3	5
LSCC	IKBKG →	-0.166	-0.074	.001	<.001	2	6
HNSC	NOTCH3 →	+0.484	+0.081	<.001	.008	3	5
HNSC	F11R →	+0.506	+0.101	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060669 vs MYO18A — HNSC

Explore this scatter interactively →