Embryonic placenta morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic placenta morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JADE3, QTRT1, and PRR7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, JADE3 grouped by Embryonic placenta morphogenesis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	JADE3 →	-0.620	-1.124	.007	.002	3	4
BONE	QTRT1 →	-0.923	-1.416	.002	.001	3	4
BLOOD_Leukemia	PRR7 →	-0.938	-1.399	.002	.001	3	4
BLOOD_Leukemia	NAP1L5 →	+2.020	+1.508	.001	.008	3	3
LUNG_NSCLC_LUSC	NAT1 →	+1.373	+1.560	.004	<.001	3	3
LUNG_NSCLC_LUSC	DCTPP1 →	-0.576	-1.319	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JADE3 by Embryonic placenta morphogenesis activity — CNS

Explore this box plot interactively →