Embryonic placenta morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic placenta morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGFR2, BMP7, and FGFR3, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic placenta morphogenesis activity versus FGFR2 in SOFT_TISSUE (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FGFR2 →	+2.670	+0.702	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	BMP7 →	+3.799	+0.492	<.001	.007	2	13
URINARY_TRACT	FGFR3 →	+2.860	+0.710	<.001	.004	3	9
CNS	WNT7B →	+2.351	+0.761	<.001	.007	2	10
LIVER	IGF2 →	+7.772	+1.680	<.001	<.001	3	9
URINARY_TRACT	BTG2 →	+2.512	+0.723	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060669 vs FGFR2 — SOFT_TISSUE

Explore this scatter interactively →